In some cases, when spacedesk is connected over USB tethering connection, the USB driver used by USB tethering network causes a BSOD crash.
Please try to update the Windows USB driver via Windows Update.

In case of BSOD(Blue Screen of Death) crash during installation, check if CH Products drivers (e.g. Joysticks and other control devices) is currently installed and active in the primary machine. This driver is currently incompatible with spacedesk driver. (Reference: Incompatible Third Party Products)